Argatroban monohydrate

SIGMA/A0487 - ≥98% (HPLC)

Synonym: (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid; Argipidine; MQPA

CAS Number: 141396-28-3
Empirical Formula (Hill Notation): C₂₃H₃₆N₆O₅S · H₂O
Molecular Weight: 526.65
MDL Number: MFCD23105684
Linear Formula: C₂₃H₃₆N₆O₅S · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A0487-5MG	5 mg	$92.70 1/EA	Add To Favorites
45-A0487-25MG	25 mg	$375.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C23H36N6O5S.H2O/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19;/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26);1H2/t14-,15?,17?,18-;/m1./s1
InChI key	AIEZTKLTLCMZIA-LINCPPCXSA-N
originator	Baxter
Quality Level	100
SMILES string	[S](=O)(=O)(NC(CCCNC(=N)N)C(=O)N3[C@H](C[C@@H](CC3)C)C(=O)O)c1c2c(ccc1)CC(CN2)C.O
solubility	DMSO: ≥20 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	Argatroban monohydrate has been used as a thrombin-selective inhibitor in the thrombin assay of platelet poor plasma samples. It may be used as a standard in gradient reversed-phase liquid chromatography coupled with high-resolution multistage mass spectrometry (LC/HR-MSⁿ) for photoproducts fragmentation analysis and as a thrombin inhibitor competitive assay with fullerene-based C60 nanoparticle (NPs).
Biochem/physiol Actions:	Argatroban has a high affinity and binds to arginine in thrombin active site resulting in steric hindrance for substrate binding. Argatroban is effective in preventing thrombus formation and favors thrombolysis than unfractionated heparin. It is recommended for acute ischemic stroke treatment.
Biochem/physiol Actions:	Argatroban is a potent, selective, direct inhibitor of thrombin and a clinical anticoagulant.
Biochem/physiol Actions:	Argatroban is a potent, seletive, univalent direct inhibitor of thrombin. It directly inhibits thrombin by binding only to its active site (thus univalent) as compared to Bivalent DTIs (hirudin and analogs) which bind both to the active site and exosite 1.
Features and Benefits:	This compound was developed by Baxter . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Argatroban anticoagulant is synthesized from L-arginine and photodegrades under light exposure.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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