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Aurothioglucose hydrate

SIGMA/A0606 - ≥96% (titration)

Synonym: Gold thioglucose; Solganal; Solganol

CAS Number: 12192-57-3 (anhydrous)
Empirical Formula (Hill Notation): C6H11AuO5S · xH2O
Molecular Weight: 392.18 (anhydrous basis)
EC Number: 235-365-7
Linear Formula: C6H11AuO5S · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A0606-5MG 5 mg
 $222.00
1/EA		 Add To Favorites
45-A0606-25MG 25 mg
 $763.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts A0606-25MG

 

assay ≥96% (titration)
color white to beige
form powder
InChI 1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1
InChI key SGVIEHTYEMEDRR-PKXGBZFFSA-M
Quality Level 100 
SMILES string O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O
solubility H2O: 5 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.
Biochem/physiol Actions: Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.
Biochem/physiol Actions: Potent PKCι-Par6 interaction inhibitor
Features and Benefits: This compound is featured on the PKC  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H317 - H334
Precautionary statements P261 - P280 - P342 + P311
Hazard Codes Xn
Risk Statements 42/43
Safety Statements 22-36/37-45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥96% (titration)
Storage Temp. 2-8°C
UNSPSC 12352200

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