N-Acetyl-Asp-Glu-Val-Asp-al
SIGMA/A0835 - ≥95%, powder
Synonym: Ac-DEVD-CHO
CAS Number: 169332-60-9
Empirical Formula (Hill Notation): C20H30N4O11
Molecular Weight: 502.47
MDL Number: MFCD00671412
Linear Formula: C20H30N4O11
Product Type: Chemical
assay | ≥95% |
biological source | synthetic |
color | white |
form | powder |
InChI | 1S/C20H30N4O11/c1-9(2)17( |
InChI key | UMBVAPCONCILTL-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | [H]C(=O)C(CC(O)=O)NC(=O)C |
solubility | H2O: 1 mg/mL |
storage temp. | −20°C |
Amino Acid Sequence: | NAc-Asp-Glu-Val-Asp-al |
Application: | N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells. |
Biochem/physiol Actions: | N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality. |
Biochem/physiol Actions: | Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3). |
General description: | N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% |
Storage Temp. | −20°C |
UNSPSC | 12352209 |