Aurintricarboxylic acid ammonium salt
SIGMA/A0885 - powder
Synonym: ATA; Aluminon; Ammonium aurintricarboxylate
CAS Number: 569-58-4
Empirical Formula (Hill Notation): C22H23N3O9
Molecular Weight: 473.43
EC Number: 209-319-1
MDL Number: MFCD00040925
Linear Formula: C22H14O9 · 3NH3
Product Type: Chemical
λmax | 552 nm (λmax: ) |
application(s) | diagnostic assay manufacturing hematology histology |
biological source | synthetic |
color | dark red |
form | powder |
InChI | 1S/C22H14O9.3H3N/c23-16-4 |
InChI key | AIPNSHNRCQOTRI-UHFFFAOYSA |
mp | 220-225 °C (dec.) (lit.) |
Quality Level | 200 |
SMILES string | N.N.N.OC(=O)c1cc(ccc1O)C |
solubility | water: soluble 100 mg/mL, dark red |
storage temp. | room temp |
Application: | Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection. |
Biochem/physiol Actions: | Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis. |
Other Notes: | May contain a substantial amount of polymeric material. |
Packaging: | 25 g in glass bottle |
Hazard Codes | Xi |
Risk Statements | 36/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
mp | 220-225 °C (dec.) (lit.) |
Storage Temp. | room temp |
Colour Index Number | 43810 |
UNSPSC | 12171500 |