AM281

SIGMA/A0980 - ≥98% (HPLC)

Synonym: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide; AM 281

CAS Number: 202463-68-1
Empirical Formula (Hill Notation): C₂₁H₁₉Cl₂IN₄O₂
Molecular Weight: 557.21
MDL Number: MFCD01861180
Linear Formula: C₂₁H₁₉Cl₂IN₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A0980-10MG	10 mg	$381.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
InChI key	AJFFBPZYXRNAIC-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4
solubility	DMSO: >6 mg/mL
	H₂O: insoluble
storage condition	desiccated
storage temp.	2-8°C

Application:	AM281 has been used as a cannabinoid 1 receptor antagonist: • to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice • to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments • to study its effect on scopolamine-induced memory deficit using object recognition paradigm • to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain
Biochem/physiol Actions:	AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice.
Biochem/physiol Actions:	Potent and selective CB₁ cannabinoid receptor antagonist/inverse agonist
Features and Benefits:	This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 - H315 - H319 - H335
Precautionary statements	P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	25-36/37/38
Safety Statements	26-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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