Amyloid β Protein Fragment 1-40
SIGMA/A1075 - ≥90% (HPLC), powder
Synonym: Aβ40
CAS Number: 131438-79-4
Empirical Formula (Hill Notation): C194H295N53O58S
Molecular Weight: 4329.80
MDL Number: MFCD00130509
Linear Formula: C194H295N53O58S
Product Type: Chemical
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| assay | ≥90% (HPLC) |
| color | white |
| form | powder |
| Quality Level | 200  |
| solubility | 1% acetic acid: 1 mg/mL |
| saline: insoluble | |
| storage temp. | −20°C |
| UniProt accession no. | P05067  |
| Amino Acid Sequence: | Asp-Ala-Glu-Phe-Arg-His-A |
| Application: | Amyloid β Protein Fragment 1-40 has been used: • in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies • as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma • as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts |
| Biochem/physiol Actions: | Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease. |
| Biochem/physiol Actions: | Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels. |
| General description: | Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium. |
| Other Notes: | Lyophilized from 0.1% TFA in H2O |
| Preparation Note: | For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |