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BAPTA-AM

SIGMA/A1076 - ≥95% (HPLC)

Synonym: 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)

CAS Number: 126150-97-8
Empirical Formula (Hill Notation): C34H40N2O18
Molecular Weight: 764.68
MDL Number: MFCD00036696
Linear Formula: C34H40N2O18
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A1076-25MG 25 mg
 $310.00
1/EA		 Add To Favorites
Representative of vacuum-sealed clear ampule packaging. Non-uniform tips are an inherent feature in this sealing process.

 

assay ≥95% (HPLC)
form powder
InChI 1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI key YJIYWYAMZFVECX-UHFFFAOYSA-N
Quality Level 200 
SMILES string CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccccc1OCCOc2ccccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O
storage temp. −20°C
Application: BAPTA-AM has been used :
• to reduce the elevation of cleaved caspase-3
• to block cell death, inhibit ROS (reactive oxygen species) production and inhibit caspase-8 activation
• to exclude the effect of changes in intracellular Ca2+ ([Ca2+]i) concentration during seizure induction
• to eliminate the increase of [Ca2+]i induced by 6-hydroxydopamine (6-OHDA)
Biochem/physiol Actions: Selective chelator of intracellular Ca2+ stores.
General description: BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+ channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.
Other Notes: Membrane-permeable form of BAPTA.
Packaging: 25 mg in ampule
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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