N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin

SIGMA/A1086 - ≥97% (HPLC), powder

Synonym: Ac-DEVD-AMC

CAS Number: 169332-61-0
Empirical Formula (Hill Notation): C₃₀H₃₇N₅O₁₃
Molecular Weight: 675.64
MDL Number: MFCD00671411
Linear Formula: C₃₀H₃₇N₅O₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A1086-5MG	5 mg	$525.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white
composition	Peptide content, ~65%
form	powder
InChI	1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1
InChI key	ALZSTTDFHZHSCA-RNVDEAKXSA-N
Quality Level	100
SMILES string	CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1
solubility	DMSO: 10 mM
storage temp.	−20°C

Application:	N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin has been used as a substrate for caspase-3 assay in human colon cancer cell line and in bone marrow mesenchymal stem cells.
Biochem/physiol Actions:	Fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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