DMT-dA(bz) Phosphoramidite

SIGMA/A111080 - configured for PerkinElmer, configured for Polygen

Synonym: DMT-dA(bz) Amidite; N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyadenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyadenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS Number: 98796-53-3
Empirical Formula (Hill Notation): C₄₇H₅₂N₇O₇P
Molecular Weight: 857.93
MDL Number: MFCD00036314
Linear Formula: C₄₇H₅₂N₇O₇P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A111080-12X1G	1 g	$329.00 12/EA	Add To Favorites
45-A111080-12X2G	2 g	$675.00 12/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥99% (³¹P-NMR)
	≥99.0% (reversed phase HPLC)
biological source	non-animal source (no BSE/TSE risk)
bottle volume	1 and 2 oz (30 and 60 mL)
color	white to off-white
compatibility	configured for Expedite^™ and PolyGen^®
	configured for PerkinElmer
	configured for Polygen
form	powder or granules
impurities	≤0.3 wt. % water content (Karl Fischer)
InChI	1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1
InChI key	GGDNKEQZFSTIMJ-AKWFTNRHSA-N
neck size	20-400
nucleoside profile	base: deoxyadenosine base protecting group: benzoyl 2' protecting group: none 5' protecting group: DMT deprotection: standard
product line	Proligo Reagents
Quality Level	200
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
solubility	0.1 g/L at 68 °F
storage temp.	2-8°C
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

General description:	Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib))Key features of DNA phosphoramidites :• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides • The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides The product belongs to Expedite^™ and PolyGen® Synthesizers synthesizers.
Legal Information:	Expedite is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries
Legal Information:	PolyGen is a registered trademark of PolyGen GmbH.
Packaging:	packaged in a 1oz bottle with a 20-400 cap

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp.	2-8°C
UNSPSC	41116107

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