DMT-dA(tac) Phosphoramidite

SIGMA/A112030 - configured for ABI

Synonym: DMT-dA(tac) amidite

CAS Number: 149989-58-2
Empirical Formula (Hill Notation): C₅₂H₆₂N₇O₈P
Molecular Weight: 944.06
MDL Number: MFCD00058443
Linear Formula: C₅₂H₆₂N₇O₈P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A112030-12X1G	1 g	$609.00 12/EA	Add To Favorites
45-A112030-12X2G	2 g	$1220.00 12/EA	Add To Favorites
45-A112030-12X4G	4 g	$2180.00 12/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥98% (³¹P-NMR)
	≥98.0% (reversed phase HPLC)
compatibility	configured for ABI
form	powder
InChI	1S/C48H54N7O8P/c1-33(2)55(34(3)4)64(61-27-13-26-49)63-41-28-44(54-32-52-45-46(50-31-51-47(45)54)53-43(56)30-59-40-16-11-8-12-17-40)62-42(41)29-60-48(35-14-9-7-10-15-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,31-34,41-42,44H,13,27-30H2,1-6H3,(H,50,51,53,56)/t41-,42+,44+,64?/m0/s1
InChI key	INUFZOANRLMUCW-SDNJGBRXSA-N
nucleoside profile	base: deoxyadenosine base protecting group: TAC 2' protecting group: none 5' protecting group: DMT deprotection: fast
product line	Proligo Reagents
Quality Level	200
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)COc5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
storage temp.	−20°C
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

General description:

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides. Substitution of standard protecting groups with the labile TAC (tert.-butylphenoxyacetyl) protecting group results in ultra-fast and easy deprotection under mild conditions, suitable for oligonucleotides with base labile monomers and reporters as well as in-situ synthesis schemes on glass surfaces. Key Features of TAC Chemistry:• Deprotection of the TAC group is ultra-fast: complete deprotection in concentrated ammonia occurs within 15 minutes at 55 °C or two hours atroom temperature
• Compatible with the AMA deprotection reagent (a mixture of ≥25%ammonia in water with 40% aqueous methylamine I/I, v/v)
• Highly soluble in acetonitrile. No need to add co-solvents such as dimethylformamide or methylene chloride
• Suitable for the synthesis of oligomers with base-labile units e.g., dyes and modifiers, because of less exposure to ammonia and the possibility ofroom temperature deprotection
• No change is required in the reagents commonly used for DNA synthesis,except that Proligo′s Fast Deprotection Cap A solution is used instead ofCap A solution
• The application of dA(tac) minimizes depurination and improves thequality of oligonucleotides
DMT-dA(tac) Phosphoramidite configured for ABI Synthesizers.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (³¹P-NMR); ≥98.0% (reversed phase HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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