AH6809
SIGMA/A1221 - ≥98%, crystalline solid or supercooled liquid
Synonym: 6-
CAS Number: 33458-93-4
Empirical Formula (Hill Notation): C17H14O5
Molecular Weight: 298.29
MDL Number: MFCD08056083
Linear Formula: C17H14O5
Product Type: Chemical
| assay | ≥98% |
| form | crystalline solid or supercooled liquid |
| InChI | 1S/C17H14O5/c1-9(2)21-11- |
| InChI key | AQFFXPQJLZFABJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(C)Oc1ccc2c(Oc3ccc(cc3C |
| solubility | DMSO or DMF: soluble 8 mg/mL |
| ethanol: soluble 2.5 mg/mL |
| Application: | AH6809 has been used: • as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia • as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines • as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP) |
| Biochem/physiol Actions: | AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines. |
| Biochem/physiol Actions: | DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP1 and EP2 prostanoid receptors. |
| Features and Benefits: | This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| UNSPSC | 12352200 |