AMPK (α1/β1/γ1), active, His tagged human
SIGMA/A1233 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: AMPKG; HAMPKb; MGC17785; MGC33776; MGC57364; MGC8666; PRKAA1; PRKAB1; PRKAG1
Product Type: Chemical
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| application(s) | life science and biopharma |
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | A1 subunit ~68 kDa |
| B1 subunit ~38 kDa | |
| G1 subunit ~40 kDa | |
| product line | PRECISIO® Kinase |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| solubility | water: soluble |
| specific activity | 626-848 nmol/min·mg |
| storage temp. | −70°C |
| UniProt accession no. | P54619  |
| Q13131 |
|
| Q9Y478 |
| Application: | AMP-activated protein kinase (AMPK) has been used to access the binding kinetics of thalidezine to recombinant active human AMPK using Bio-Layer Interferometry (BLI) binding assay. |
| Biochem/physiol Actions: | AMP-activated protein kinase (AMPK) is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated and phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and 3-hydroxy-3-methylglutary |
| General description: | Research area: CELL SIGNALING AMP-activated protein kinase (AMPK) is a heterotrimer protein kinase consisting of a α catalytic subunit, and non-catalytic β and γ subunits. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol. |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H319 - H360D |
| Precautionary statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 626-848 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |