Amantadine hydrochloride

SIGMA/A1260

Synonym: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride; NSC 83653; Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride

CAS Number: 665-66-7
Empirical Formula (Hill Notation): C₁₀H₁₇N · HCl
Molecular Weight: 187.71
EC Number: 211-560-2
MDL Number: MFCD00074723
Linear Formula: C₁₀H₁₇N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A1260-5G	5 g	$72.70 1/EA	Add To Favorites
45-A1260-25G	25 g	$299.00 1/EA	Add To Favorites
45-A1260-100G	100 g	$729.00 1/EA	Add To Favorites

ATR-IR Spectra for 1-Adamantanamine hydrochloride.

FT-IR Raman Spectra for 1-Adamantanamine hydrochloride.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A1260-100G

Properties
Descriptions
Safety Info.
Basic Data

form	powder
InChI	1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI key	WOLHOYHSEKDWQH-SOVZANNPSA-N
originator	Endo
Quality Level	100
SMILES string	Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
solubility	ethanol: soluble
	H₂O: 50 mg/mL

Application:	Amantadine hydrochloride has been used: • to determine its effectiveness in reducing surgery-induced cognitive impairment • to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway • to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory • to preincubate primary cultured rat dental pulp stem cells (rDPSCs) • to determine the pathway of internalization
Biochem/physiol Actions:	Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.
Biochem/physiol Actions:	Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Endo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.
Packaging:	5, 25, 100 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352200

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