Amantadine hydrochloride

SIGMA/A1260

Synonym: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride; NSC 83653; Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride

CAS Number: 665-66-7
Empirical Formula (Hill Notation): C₁₀H₁₇N · HCl
Molecular Weight: 187.71
EC Number: 211-560-2
MDL Number: MFCD00074723
Linear Formula: C₁₀H₁₇N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A1260-5G	5 g	$65.90 1/EA	Add To Favorites
45-A1260-25G	25 g	$271.00 1/EA	Add To Favorites
45-A1260-100G	100 g	$661.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

form	powder
InChI	1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI key	WOLHOYHSEKDWQH-SOVZANNPSA-N
originator	Endo
Quality Level	100
SMILES string	Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
solubility	ethanol: soluble
	H₂O: 50 mg/mL

Application:	Amantadine hydrochloride has been used: • to determine its effectiveness in reducing surgery-induced cognitive impairment • to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway • to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory • to preincubate primary cultured rat dental pulp stem cells (rDPSCs) • to determine the pathway of internalization
Biochem/physiol Actions:	Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.
Biochem/physiol Actions:	Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Endo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.
Packaging:	5, 25, 100 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352200

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