Amastatin hydrochloride hydrate
SIGMA/A1276 - ≥97% (HPLC)
Synonym: (2S,3R)
CAS Number: 100938-10-1
Empirical Formula (Hill Notation): C21H38N4O8 · HCl · xH2O
Molecular Weight: 511.01 (anhydrous basis)
MDL Number: MFCD00150636
Linear Formula: C21H38N4O8 · HCl · xH2O
Product Type: Chemical
antibiotic activity spectrum | neoplastics |
assay | ≥97% (HPLC) |
biological source | synthetic (organic) |
form | powder |
InChI | 1S/C21H38N4O8.ClH.H2O/c1- |
InChI key | WBYDQJQQTMJMQH-AFROIDPFSA |
mode of action | enzyme | inhibits |
mp | 202-205 °C |
Quality Level | 200 |
SMILES string | Cl[H].[H]O[H].CC(C)C[C@@H |
solubility | methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.) |
storage temp. | −20°C |
Biochem/physiol Actions: | It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo. Effective concentration: 1-10 μM. |
General description: | Chemical structure: peptide |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
mp | 202-205 °C |
Storage Temp. | −20°C |
UNSPSC | 12352202 |