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Amastatin hydrochloride hydrate

SIGMA/A1276 - ≥97% (HPLC)

Synonym: (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate

CAS Number: 100938-10-1
Empirical Formula (Hill Notation): C21H38N4O8 · HCl · xH2O
Molecular Weight: 511.01 (anhydrous basis)
MDL Number: MFCD00150636
Linear Formula: C21H38N4O8 · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A1276-.5MG 0.5 mg
 $196.00
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45-A1276-1MG 1 mg
 $312.00
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45-A1276-5MG 5 mg
 $1120.00
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45-A1276-10MG 10 mg
 $1790.00
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45-A1276-25MG 25 mg
 $3740.00
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antibiotic activity spectrum neoplastics
assay ≥97% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C21H38N4O8.ClH.H2O/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H;1H2/t12-,13+,15+,16+,17+;;/m1../s1
InChI key WBYDQJQQTMJMQH-AFROIDPFSA-N
mode of action enzyme | inhibits
mp 202-205 °C
Quality Level 200 
SMILES string Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
solubility methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)
storage temp. −20°C
Biochem/physiol Actions: Amastatin is a slow, tight-binding inhibitor of aminopeptidases. It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts Angiotensin II to Angiotensin III. Effective concentration: 1-10 μM.
Biochem/physiol Actions: It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.

Effective concentration: 1-10 μM.
General description: Chemical structure: peptide
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
mp 202-205 °C
Storage Temp. −20°C
UNSPSC 12352202

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