Amoxapine
SIGMA/A129
Synonym: 2-
CAS Number: 14028-44-5
Empirical Formula (Hill Notation): C17H16ClN3O
Molecular Weight: 313.78
EC Number: 237-867-1
MDL Number: MFCD00069210
Linear Formula: C17H16ClN3O
Product Type: Chemical
| form | powder |
| InChI | 1S/C17H16ClN3O/c18-12-5-6 |
| InChI key | QWGDMFLQWFTERH-UHFFFAOYSA |
| originator | Wyeth |
| Quality Level | 100  |
| SMILES string | Clc1ccc2Oc3ccccc3N=C(N4CC |
| solubility | methanol: soluble |
| Application: | Amoxapine has been used as an antidepressant drug to test its effect on locomotion and egg release in response to gain-of-functional mutations in potassium (K+) channels (unc-58) of C. elegans. It has also been used as an antipsychotic drug to test its effect on the viability of glioblastoma cells. |
| Biochem/physiol Actions: | Amoxapine, a structural analog of clozapine, is a human ether a-go-go (hERG) channel blocker. It is also an N-methylated metabolite of loxapine. It is a tricyclic antidepressant that inhibits the uptake of norepinephrine and blocks 5- hydroxytryptamine (HT2 ) serotonergic receptors. |
| Features and Benefits: | This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Wyeth . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352200 |