β-Amanitin from Amanita phalloides
SIGMA/A1304 - ≥85% (HPLC)
CAS Number: 21150-22-1
Empirical Formula (Hill Notation): C39H53N9O15S
Molecular Weight: 919.95
EC Number: 244-244-8
MDL Number: MFCD00151212
Linear Formula: C39H53N9O15S
Product Type: Chemical
assay | ≥85% (HPLC) |
form | powder |
InChI | 1S/C39H53N9O15S/c1-4-16(2 |
InChI key | IEQCUEXVAPAFMQ-UHFFFAOYSA |
Quality Level | 200 |
SMILES string | CCC(C)C1NC(=O)CNC(=O)C2Cc |
storage temp. | −20°C |
Application: | β-Amanitin from Amanita phalloides has been used: • as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method. • to determine its concentration in urine samples by capillary zone electrophoresis (CZE). • in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry. |
Biochem/physiol Actions: | Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis. |
General description: | β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature. |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H300 - H310 - H330 |
Precautionary statements | P260 - P264 - P280 - P284 - P302 + P350 - P310 |
Hazard Codes | T+ |
Risk Statements | 26/27/28 |
Safety Statements | 7-28-36/37/39-45 |
RIDADR | UN 3462 6.1 / PGI |
WGK Germany | WGK 3 |
Purity | ≥85% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |