β-Amanitin from Amanita phalloides

SIGMA/A1304 - ≥85% (HPLC)

CAS Number: 21150-22-1
Empirical Formula (Hill Notation): C₃₉H₅₃N₉O₁₅S
Molecular Weight: 919.95
EC Number: 244-244-8
MDL Number: MFCD00151212
Linear Formula: C₃₉H₅₃N₉O₁₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A1304-1MG	1 mg	$953.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (HPLC)
form	powder
InChI	1S/C39H53N9O15S/c1-4-16(2)31-36(60)41-11-28(53)42-25-15-64(63)38-21(20-6-5-18(50)7-22(20)45-38)9-23(33(57)40-12-29(54)46-31)43-37(61)32(17(3)27(52)14-49)47-35(59)26-8-19(51)13-48(26)39(62)24(10-30(55)56)44-34(25)58/h5-7,16-17,19,23-27,31-32,45,49-52H,4,8-15H2,1-3H3,(H,40,57)(H,41,60)(H,42,53)(H,43,61)(H,44,58)(H,46,54)(H,47,59)(H,55,56)
InChI key	IEQCUEXVAPAFMQ-UHFFFAOYSA-N
Quality Level	200
SMILES string	CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(O)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2
storage temp.	−20°C

Application:	β-Amanitin from Amanita phalloides has been used: • as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method. • to determine its concentration in urine samples by capillary zone electrophoresis (CZE). • in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.
Biochem/physiol Actions:	Inhibits eukaryotic RNA polymerase II and III; does not inhibit RNA polymerase I or bacterial RNA polymerase; inhibits mammalian protein synthesis.
Biochem/physiol Actions:	Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
General description:	β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 - H310 - H330
Precautionary statements	P260 - P264 - P280 - P284 - P302 + P350 - P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	7-28-36/37/39-45
RIDADR	UN 3462 6.1 / PGI
WGK Germany	WGK 3

Purity	≥85% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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