Adenosine 5′-[γ-thio]triphosphate tetralithium salt

SIGMA/A1388 - ≥75% (HPLC), powder

Synonym: ATP-γ-S; Adenosine 5′-(3-thiotriphosphate) tetralithium salt; Ado-5′-PPP[S]

CAS Number: 93839-89-5
Empirical Formula (Hill Notation): C₁₀H₁₂Li₄N₅O₁₂P₃S
Molecular Weight: 546.98
EC Number: 298-862-8
MDL Number: MFCD00077293
Linear Formula: C₁₀H₁₂Li₄N₅O₁₂P₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A1388-1MG	1 mg	$118.00 1/EA	Add To Favorites
45-A1388-5MG	5 mg	$282.00 1/EA	Add To Favorites
45-A1388-25MG	25 mg	$693.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A1388-1MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥75% (HPLC)
biological source	synthetic (organic)
color	off-white
form	powder
InChI	1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChI key	DWQFDOIBOYDYKH-KWIZKVQNSA-J
Quality Level	200
shipped in	dry ice
SMILES string	[Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
solubility	H₂O: 25 mg/mL
storage temp.	−20°C

Application:	Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product. It has also been used to select thiophosphorylate target protein.
Biochem/physiol Actions:	Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca²⁺-activated K⁺ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.
Other Notes:	Non-hydrolyzable ATP analog
Packaging:	1, 5 mg in glass bottle
Packaging:	25 mg in poly bottle

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥75% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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