Pituitary adenylate cyclase activating polypeptide-38
SIGMA/A1439
Synonym: PACAP-38
CAS Number: 137061-48-4
Empirical Formula (Hill Notation): C203H331N63O53S
Molecular Weight: 4534.26
MDL Number: MFCD00081800
Linear Formula: C203H331N63O53S
Product Type: Chemical
| composition | Peptide content, ~70% |
| form | powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| UniProt accession no. | P18509  |
| Amino Acid Sequence: | His-Ser-Asp-Gly-Ile-Phe-T |
| Application: | Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects. |
| Biochem/physiol Actions: | PACAP-38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). It is reported to serve as a neuronal survival factor. |
| Biochem/physiol Actions: | Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a cardioprotectant and may help in treating radiation-induced heart disease (RIHD). It plays a protective role during oxidative stress in cardiomyocytes. PACAP38 has antioxidant, anti-apoptotic and anti-inflammatory property. It is implicated in the pathophysiology of migraine and cluster headache. |
| General description: | Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals. |
| Other Notes: | Lyophilized from 0.1% TFA in H2O |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |