MCA-[Asn⁶⁷⁰, Leu⁶⁷¹]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676-DNP-Lys-Arg-Arg-NH₂

SIGMA/A1472 - ≥90% (HPLC)

Synonym: 7-Methoxycoumarin-4-acetyl-[Asn⁶⁷⁰, Leu⁶⁷¹]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676(2,4-dinitrophenyl)Lys-Arg-Arg amide

Empirical Formula (Hill Notation): C₈₆H₁₂₅N₂₇O₂₉
Molecular Weight: 2001.08
MDL Number: MFCD03454237
Linear Formula: C₈₆H₁₂₅N₂₇O₂₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A1472-1MG	1 mg	$549.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
Quality Level	100
storage temp.	−20°C
UniProt accession no.	P05067

Amino Acid Sequence:	MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-DNP-Lys-Arg-Arg-NH2
Application:	7-Methoxycoumarin-4-acetyl-[Asn⁶⁷⁰,Leu⁶⁷¹]-Amyloid β has been used as a fluorogenic substrate to measure β-secretase activity.
Biochem/physiol Actions:	Fluorescent peptide substrate containing the ′Swedish′ Lys-Met/Asn-Leu mutation of the amyloid presursor protein (APP) β-secretase cleavage site. May be used for assaying β-secretase-like activity of thimet oligopeptidase (TOP), EC 3.4.24.15.
Biochem/physiol Actions:	Fluorescent peptide substrate with the ′Swedish′ Lys-Met/Asn-Leu mutation of amyloid presursor protein (APP) β-secretase cleavage site.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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