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Adrenocorticotropic Hormone Fragment 7-38 human

SIGMA/A1527 - ≥97% (HPLC)

CAS Number: 68563-24-6
Empirical Formula (Hill Notation): C167H257N47O46
Molecular Weight: 3659.11
MDL Number: MFCD00081282
Linear Formula: C167H257N47O46
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A1527-250UG 250 µg
 $231.00
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45-A1527-.5MG 0.5 mg
 $363.00
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45-A1527-1MG 1 mg
 $594.00
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assay ≥97% (HPLC)
form powder
Quality Level 200 
sterility non-sterile
storage temp. −20°C
UniProt accession no. P01189 
Amino Acid Sequence: Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu
Application: Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.
Biochem/physiol Actions: Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.
Other Notes: ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Other Notes: Lyophilized from 0.1% TFA in H2O
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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