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Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt

SIGMA/A165 - powder, ≥98% (HPLC)

Synonym: Rp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine triethylammonium salt; Rp-cAMPS triethylammonium salt

CAS Number: 151837-09-1 (anhydrous)
Empirical Formula (Hill Notation): C10H11N5O5PS · C6H16N
Molecular Weight: 446.46
MDL Number: MFCD03703495
Linear Formula: C10H11N5O5PS · C6H16N
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A165-1MG 1 mg
 $189.00
1/EA		 Add To Favorites
45-A165-5MG 5 mg
 $782.00
1/EA		 Add To Favorites
45-A165-10MG 10 mg
 $1470.00
1/EA		 Add To Favorites

 

λmax 258 nm
assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1
InChI key OXIPZMKSNMRTIV-NVGWRVNNSA-N
Quality Level 100 
SMILES string CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O
solubility H2O: 10 mg/mL
storage condition desiccated
storage temp. −20°C
Application: Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt has been used as an antagonist of cAMP to block the cAMP-PKA signal pathway.
Biochem/physiol Actions: Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt is capable of inhibiting protein kinase A (PKA).
Biochem/physiol Actions: Rp-Diastereomer of adenosine-3′,5′-cyclic monophosphothioate. Specific membrane-permeable inhibitor of activation by cAMP of cAMP-dependent protein kinase I and II; resistant toward cyclic nucleotide phosphodiesterases; blocks cAMP-mediated effects in numerous systems.
Caution: Extremely hygroscopic. Store desiccated.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1, 5, 10 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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