A922500
SIGMA/A1737
CAS Number: 959122-11-3
Empirical Formula (Hill Notation): C26H24N2O4
Molecular Weight: 428.48
Linear Formula: C26H24N2O4
Product Type: Chemical
| assay | >95% (HPLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C26H24N2O4/c29-24(22-7 |
| InChI key | BOZRFEQDOFSZBV-DHIUTWEWSA |
| mol wt | Mw 428.5 |
| Quality Level | 100  |
| solubility | DMSO: 10 mg/mL, clear, colorless to greenish-yellow |
| storage temp. | −20°C |
| Application: | A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages. |
| Biochem/physiol Actions: | Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC50 7 to 24 nM |
| Biochem/physiol Actions: | The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease. |
| Packaging: | 1, 5, 10 mg in glass bottle |
| Physical form: | A922500 is supplied as a crystalline solid. |
| Preparation Note: | A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). |
| Hazard Codes | T,N |
| Risk Statements | 25-36-50 |
| Safety Statements | 26-45-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |