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N-Acetyl-5-hydroxytryptamine

SIGMA/A1824 - ≥99% (HPLC), powder

Synonym: N-Acetylserotonin; Normelatonin

CAS Number: 1210-83-9
Empirical Formula (Hill Notation): C12H14N2O2
Molecular Weight: 218.25
EC Number: 214-916-5
MDL Number: MFCD00005656
Linear Formula: C12H14N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A1824-100MG 100 mg
 $153.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A1824-100MG

 

assay ≥99% (HPLC)
color white to faint yellow
form powder
InChI 1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
InChI key MVAWJSIDNICKHF-UHFFFAOYSA-N
mp 120-122 °C (lit.)
Quality Level 200 
SMILES string CC(=O)NCCc1c[nH]c2ccc(O)cc12
solubility ethanol: 50 mg/mL
storage temp. 2-8°C
Application: N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on Krüppel-like factor 15 (KLF15) expression.
Biochem/physiol Actions: N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.
Biochem/physiol Actions: Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.
General description: N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.
Packaging: 1 g in poly bottle
Packaging: 100, 250 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99% (HPLC)
mp 120-122 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12352209

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