Albumin from human serum
SIGMA/A1887 - lyophilized powder, essentially fatty acid free
Synonym: HSA
CAS Number: 70024-90-7
EC Number: 274-272-6
MDL Number: MFCD00081418
Product Type: Chemical
assay | ≥96% (agarose gel electrophoresis) |
biological source | human |
form | lyophilized powder |
impurities | HIV I and HIVII, HCV and HBsAg, tested negative |
≤0.007% Fatty Acids | |
InChI | 1S/C3F8/c4-1(5,2(6,7)8)3( |
InChI key | QYSGYZVSCZSLHT-UHFFFAOYSA |
mol wt | monomer calculated mol wt 66478 Da |
Quality Level | 300 |
solubility | H2O: soluble 50 mg/mL, clear to slightly hazy |
storage temp. | 2-8°C |
technique(s) | ELISA: suitable |
tissue culture: suitable | |
western blot: suitable | |
UniProt accession no. | P02768 |
Application: | Albumin from human serum has been used: • as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins • to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin • to study its effect on wound healing process |
Biochem/physiol Actions: | Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function. |
Biochem/physiol Actions: | Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer. |
Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
General description: | Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa. |
Other Notes: | View more information on human serum albumin . |
Packaging: | 1, 5, 10, 25 g in poly bottle |
Packaging: | 100, 500 mg in poly bottle |
Preparation Note: | Prepared from albumin (A1653) |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥96% (agarose gel electrophoresis) |
Storage Temp. | 2-8°C |
UNSPSC | 12352202 |