Aurintricarboxylic acid
SIGMA/A1895 - practical grade, ≥85% (titration), powder
Synonym: ATA
CAS Number: 4431-00-9
Empirical Formula (Hill Notation): C22H14O9
Molecular Weight: 422.34
EC Number: 224-628-1
MDL Number: MFCD00011663
Linear Formula: C22H14O9
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A1895-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A1895-25G
| application(s) | diagnostic assay manufacturing hematology histology |
| assay | ≥85% (titration) |
| color | red to very dark red, and Red-Brown andBrown-Red |
| form | powder |
| grade | practical grade |
| InChI | 1S/C22H14O9/c23-16-4-1-10 |
| InChI key | GIXWDMTZECRIJT-UHFFFAOYSA |
| mp | 300 °C (lit.) |
| Quality Level | 300  |
| SMILES string | OC(=O)c1cc(ccc1O)C(c2ccc |
| solubility | 1 M NH4OH: 10 mg/mL |
| storage temp. | room temp |
| Application: | • Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum. • It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransfe • It has been used as a ribonuclease inhibitor. |
| Biochem/physiol Actions: | Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis. |
| Packaging: | 5, 25 g in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% (titration) |
| mp | 300 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12171500 |