Asialofetuin from fetal calf serum
SIGMA/A1908 - Type II (Sigma designation)
MDL Number: MFCD00130561
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A1908-50MG
| biological source | bovine |
| form | powder |
| impurities | salt, essentially free |
| ≤1.0% N-acetylneuraminic acid | |
| Quality Level | 200  |
| solubility | H2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow |
| storage temp. | 2-8°C |
| technique(s) | activity assay: suitable |
| inhibition assay: suitable | |
| type | Type II (Sigma designation) |
| Application: | Asialofetuin from fetal calf serum is suitable for use: • in the assay of the lactose binding activity of the galectin-7 by immunodetection of in situ binding activity to asialofetuin immobilized on nitrocellulose • in the inhibition of zona pellucida hardening of mouse oocytes • as an acceptor in sialyltransferase enzyme activity assay |
| Application: | Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy. |
| Biochem/physiol Actions: | Asialofetuin (AF) binds to asialoglycoprotein receptor (ASGP-R) and is employed as a ligand for drug delivery to the hepatocytes. It aids serum-resistant lipoplexes for efficient gene deliver into the HepG2 (human hepatoblastoma) cells. |
| Biochem/physiol Actions: | Feutins are glycoproteins that belong to the cystatin superfamily. They are characterized by the presence of two tandemly arranged cystatin-like domains and an unrelated domain. It binds to transforming growth factor (TGF)-β/BMP (bone morphogenic protein) cytokines. |
| Packaging: | 50 mg in poly bottle |
| Preparation Note: | Enzymatic cleavage using neuraminidase |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |