Aggrecan from bovine articular cartilage
SIGMA/A1960 - lyophilized powder (from a sterile-filtered solution)
MDL Number: MFCD00676441
Product Type: Chemical
| biological source | bovine articular cartilage |
| color | white |
| form | lyophilized powder (from a sterile-filtered solution) |
| impurities | salt, essentially free |
| packaging | glass bottle of 1 mg |
| Quality Level | 200  |
| shipped in | wet ice |
| solubility | H2O: 2 mg/mL |
| sterility | sterile-filtered |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P13608  |
| Application: | Aggrecan is a critical component for cartilage structure and the function of joints. Its synthesis and degradation are being studied for their roles in cartilage deterioration during joint injury disease and aging. |
| Biochem/physiol Actions: | This molecule produces a rigid, reversibly deformable gel that resists compression. It combines with hyaluronic acid to form very large macromolecular complexes that have an increased hydrohynamic volume and a significant increase (30-40%) in the relative viscosity of the solution. |
| Caution: | Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly. |
| Components: | Aggrecan is a major structural proteoglycan of the cartilage extracellular matrix. It is a large proteoglycan, with a molecular weight greater than 2,500 kDa composed of approximately 100-150 glycosaminoglycan chains attached to a core protein. The majority of these glycosaminoglycan chains are chondroitin/dermatan sulfate. Aggrecan contains three globular domains, G1, G2, and G3, which are involved in aggregation and hylauronan binding, cell adhesion and chondrycte apoptosis. |
| Packaging: | 1 mg in glass bottle |
| Preparation Note: | This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and sterile-filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |