Apramycin sulfate salt

SIGMA/A2024

Synonym: Nebramycin II

CAS Number: 65710-07-8
Empirical Formula (Hill Notation): C₂₁H₄₁N₅O₁₁ · xH₂SO₄
Molecular Weight: 539.58 (free base basis)
EC Number: 265-890-7
MDL Number: MFCD06200257
Linear Formula: C₂₁H₄₁N₅O₁₁ · xH₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A2024-1G	1 g	$84.60 1/EA		Add To Favorites
45-A2024-5G	5 g	$292.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
biological source	Streptomyces tenebrarius
color	white to brown
form	powder
InChI	1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1
InChI key	WGLYHYWDYPSNPF-RQFIXDHTSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O
storage temp.	2-8°C

Application:	Apramycin is used to study antibiotic resistance as well as protein synthesis translocation-step inhibition in bacteria and prokaryotes.
Biochem/physiol Actions:	Apramycin inhibits protein synthesis by blocking translocation. It is also able to bind to the eukaryotic decoding site. At low concentrations it inhibits elongation and induces misreading of mRNA during protein synthesis.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.
Packaging:	1G, 5G

Symbol	GHS08
Signal word	Danger
Hazard statements	H360FD
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51101500

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