Acetyl coenzyme A trisodium salt

SIGMA/A2056 - ≥93% (HPLC), powder

Synonym: Acetyl-S- CoA; Acetyl CoA

CAS Number: 102029-73-2
Empirical Formula (Hill Notation): C₂₃H₃₅N₇O₁₇P₃S · 3Na
Molecular Weight: 875.52
MDL Number: MFCD00078858
Linear Formula: C₂₃H₃₅N₇O₁₇P₃S · 3Na
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A2056-1MG	1 mg	$69.60 1/EA	Add To Favorites
45-A2056-5MG	5 mg	$119.00 1/EA	Add To Favorites
45-A2056-10MG	10 mg	$272.00 1/EA	Add To Favorites
45-A2056-25MG	25 mg	$478.00 1/EA	Add To Favorites
45-A2056-100MG	100 mg	$1490.00 1/EA	Add To Favorites

Once transported across the mitochondrial membrane, fatty acids are metabolized through beta oxidation releasing acetyl-CoA molecules. Acetyl CoA enters the TCA cycle resulting in the production of NADH and FADH₂. NADH and FADH₂ are used by the electron transport chain to produce ATP.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2056-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥93% (HPLC)
form	powder
InChI	1S/C23H38N7O17P3S.Na/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);/q;+1/p-1/t13-,16-,17-,18?,22-;/m1./s1
InChI key	HNLIOWFIXSPFEC-WLYMNMRISA-M
Quality Level	300
SMILES string	O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[3Na]
solubility	H₂O: 100 mg/mL
storage temp.	−20°C

Application:	Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. Acetyl CoA is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Krebs cycle). Acetyl CoA is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. Acetyl CoA is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.
Application:	An essential cofactor in enzymatic acetyl transfer reactions.
Biochem/physiol Actions:	Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.
Other Notes:	For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource .
Packaging:	1, 5, 10 mg in glass bottle
Packaging:	25, 100 mg in poly bottle
Preparation Note:	Prepared enzymatically

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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