DMT-2′O-TBDMS-rA(bz) Phosphoramidite

SIGMA/A211050 - configured for (ÄKTA^® and OligoPilot^®)

Synonym: DMT-2’O-TBDMS-rA(bz) Amidite; N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS Number: 104992-55-4
Empirical Formula (Hill Notation): C₅₃H₆₆N₇O₈PSi
Molecular Weight: 988.19
MDL Number: MFCD00080297
Linear Formula: C₅₃H₆₆N₇O₈PSi
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A211050-2G	2 g	$207.00 1/EA	Add To Favorites
45-A211050-5G	5 g	$466.00 1/EA	Add To Favorites
45-A211050-10G	10 g	$1010.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥99% (³¹P-NMR)
	≥99.0% (reversed phase HPLC)
biological source	non-animal source (no BSE/TSE risk)
color	white to off-white
compatibility	configured for (ÄKTA^® and OligoPilot^®)
form	powder
impurities	≤0.3% water content (Karl Fischer)
	≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR)
	≤0.5% single Impurity (reversed phase HPLC)
	≤3% residual Solvent content
InChI	1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
InChI key	FFXHNCNNHASXCT-RFMFGJHUSA-N
nucleoside profile	base: adenosine base protecting group: benzoyl 2' protecting group: TBDMS 5' protecting group: DMT deprotection: standard
product line	Proligo Reagents
Quality Level	300
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
storage temp.	−20°C
suitability	conforms to structure for H-NMR
	conforms to structure for LC-MS
technique(s)	oligo synthesis: suitable

General description:	RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness. Key Features • Industry-standard 2′O-TBDMS protective group • Consistent lot-to-lot purity and performance • Compatible with deprotection methods based on methylamine or AMA • Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with activator 42 • Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A • Manufactured under a certified ISO 9001 quality system DMT-2′O-TBDMS-rA(bz) Phosphoramidite is configured for ÄKTA and OligoPilot Synthesizers.
Legal Information:	ÄKTA is a registered trademark of Cytiva
Legal Information:	OligoPilot is a registered trademark of Cytiva

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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