Ac-PGP trifluoroacetate salt hydrate

SIGMA/A2112 - ≥98% (HPLC)

Synonym: 1-Acetyl-L-prolylglycyl-L-proline; Acetyl Pro-Gly-Pro; Acetyl-proline-glycine-proline; N-α-PGP; acPGP

CAS Number: 292171-04-1 (free base)
Empirical Formula (Hill Notation): C₁₄H₂₁N₃O₅ · xC₂HF₃O₂ · yH₂O
Molecular Weight: 311.33 (anhydrous free base basis)
MDL Number: MFCD20134196
Linear Formula: C₁₄H₂₁N₃O₅ · xC₂HF₃O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A2112-5MG	5 mg	$106.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C14H21N3O5.C2HF3O2.H2O/c1-9(18)16-6-2-4-10(16)13(20)15-8-12(19)17-7-3-5-11(17)14(21)22;3-2(4,5)1(6)7;/h10-11H,2-8H2,1H3,(H,15,20)(H,21,22);(H,6,7);1H2/t10-,11-;;/m0../s1
InChI key	UCOFOXNKITYGTK-ULEGLUPFSA-N
Quality Level	100
shipped in	wet ice
SMILES string	O.OC(=O)C(F)(F)F.CC(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(O)=O
solubility	deionized water: ≥2 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:

N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase–8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.

Packaging:

5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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