γ-Aminobutyric acid
SIGMA/A2129 - ≥99%
Synonym: GABA; Gammalon; gamma-Aminobutyric acid; gamma-Aminobutyric acid; 3-Carboxypropylamine; 4-Aminobutanoic acid; GABA; Piperidic acid; Piperidinic acid
CAS Number: 56-12-2
Empirical Formula (Hill Notation): C4H9NO2
Molecular Weight: 103.12
EC Number: 200-258-6
MDL Number: MFCD00008226
Linear Formula: NH2(CH2)3COOH
Product Type: Chemical
| assay | ≥99% |
| color | colorless |
| form | powder or crystals |
| InChI | 1S/C4H9NO2/c5-3-1-2-4(6)7 |
| InChI key | BTCSSZJGUNDROE-UHFFFAOYSA |
| mp | 195 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | NCCCC(O)=O |
| solubility | water: 50 mg/mL, clear, colorless |
| storage condition | (Tightly closed. Dry.) |
| Application: | γ-Aminobutyric acid (GABA) has been used: • in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining • in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS) • in the intraintestinal application of GABA in order to increase intraluminal fluid secretion |
| Biochem/physiol Actions: | GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and as a neuromodulator in some peripheral tissues. It binds to the GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in a lowering of the excitability of the cell. GABAergic neurons involve myorelaxation, anxiolytic treatment, sedation, and anesthetics. GABA can also influence heart rate and blood pressure. GABA improves plasma concentration, growth hormone, and protein synthesis in the brain. It also plays a role in reducing blood pressure in humans. GABA acts as a potent hypotensive, diuretic, and antidiabetic agent. It also regulates serum lipids levels and the sensation of pain. |
| Biochem/physiol Actions: | Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance. |
| General description: | γ-Aminobutyric acid (GABA) is a non-amino protein. It is found in plants, animals, and microorganisms. GABA has been used in pharma and food industries as a component of cheese, shochu, gabaron tea, and gammalone. Research area: Neuroscience |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| mp | 195 °C (dec.) (lit.) |
| UNSPSC | 12352106 |