Advanced Search



Acetyl coenzyme A lithium salt

SIGMA/A2181 - ≥93% (HPLC)

Synonym: Acetyl-CoA; Acetyl-S-CoA Li3

CAS Number: 32140-51-5
Empirical Formula (Hill Notation): C23H38N7O17P3S · xLi+
Molecular Weight: 809.57 (free acid basis)
MDL Number: MFCD00167406
Linear Formula: C23H38N7O17P3S · xLi+
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A2181-1MG 1 mg
 $64.70
1/EA		 Add To Favorites
45-A2181-5MG 5 mg
 $103.00
1/EA		 Add To Favorites
45-A2181-10MG 10 mg
 $162.00
1/EA		 Add To Favorites
45-A2181-25MG 25 mg
 $362.00
1/EA		 Add To Favorites
45-A2181-100MG 100 mg
 $1050.00
1/EA		 Add To Favorites
Once transported across the mitochondrial membrane, fatty acids are metabolized through beta oxidation releasing acetyl-CoA molecules. Acetyl CoA enters the TCA cycle resulting in the production of NADH and FADH2. NADH and FADH2 are used by the electron transport chain to produce ATP.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2181-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2181-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2181-25MG

 

assay ≥93% (HPLC)
form powder
InChI 1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1
InChI key FTRFBNATWBKIQU-JHJDYNLLSA-K
Quality Level 300 
SMILES string [Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23
solubility H2O: soluble 100 mg/mL, clear, colorless
storage temp. −20°C
Application: Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [14C] chloramphenicol and 0.5mM acetyl-CoA.
Application: An essential cofactor in enzymatic acetyl transfer reactions.
Biochem/physiol Actions: Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.
Biochem/physiol Actions: Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea.
Other Notes: For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource .
Packaging: 1, 5 mg in glass bottle
Packaging: 10, 25, 100 mg in poly bottle
Physical properties: This moisture-sensitive powder should be stored desiccated at −20°C.
Preparation Note: Prepared enzymatically
Reconstitution: Acetyl CoA is soluble in deionized water at 100 mg/mL. Acetyl CoA is stable in neutral and moderately acidic solutions but will hydrolyze in alkaline and strongly acidic solutions. Aqueous solutions stored in single-use aliquots are stable for up to two weeks at −20°C and up to 6 months at −80°C.
Purity ≥93% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top