Amyloid β-Protein Fragment 35-25
SIGMA/A2201 - ≥95% (HPLC)
CAS Number: 147740-73-6
Empirical Formula (Hill Notation): C45H81N13O14S
Molecular Weight: 1060.27
MDL Number: MFCD00214225
Linear Formula: C45H81N13O14S
Product Type: Chemical
assay | ≥95% (HPLC) |
form | powder |
InChI | 1S/C45H81N13O14S/c1-9-24( |
InChI key | IDGOADDOQWKZOX-UHFFFAOYSA |
Quality Level | 200 |
SMILES string | CCC(C)C(NC(=O)CNC(=O)C(CC |
storage temp. | −20°C |
UniProt accession no. | P05067 |
Amino Acid Sequence: | Met-Leu-Gly-Ile-Ile-Ala-G |
Application: | Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice. |
Biochem/physiol Actions: | Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis. Amyloid β-Protein Fragment 35-25 is an inactive control. |
General description: | Amyloid β precursor protein (APP) is a type-1 transmembrane protein. APP is expressed widely and mainly found in the synapses and neurons. The APP gene is mapped to human chromosome 21q21.3. |
Other Notes: | The N—C inverted sequence of fragment 25-35 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |