Adrenomedullin 52 human
SIGMA/A2327 - ≥90% (HPLC), powder
CAS Number: 148498-78-6
Empirical Formula (Hill Notation): C264H406N80O77S3
Molecular Weight: 6028.73
MDL Number: MFCD00211549
Linear Formula: C264H406N80O77S3
Product Type: Chemical
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| assay | ≥90% (HPLC) |
| form | powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| UniProt accession no. | P35318  |
| Amino Acid Sequence: | Tyr-Arg-Gln-Ser-Met-Asn-A |
| Application: | Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs). |
| Biochem/physiol Actions: | Elicits a potent hypotensive effect; plays a key role in regulating endometrial angiogenesis. |
| Biochem/physiol Actions: | Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis. |
| General description: | Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |