Adrenomedullin 52 human
SIGMA/A2327 - ≥90% (HPLC), powder
CAS Number: 148498-78-6
Empirical Formula (Hill Notation): C264H406N80O77S3
Molecular Weight: 6028.73
MDL Number: MFCD00211549
Linear Formula: C264H406N80O77S3
Product Type: Chemical
assay | ≥90% (HPLC) |
form | powder |
Quality Level | 200 |
storage temp. | −20°C |
UniProt accession no. | P35318 |
Amino Acid Sequence: | Tyr-Arg-Gln-Ser-Met-Asn-A |
Application: | Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs). |
Biochem/physiol Actions: | Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis. |
General description: | Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥90% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 51111800 |