S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt

SIGMA/A2408 - ≥80% (HPLC), ≥80% (spectrophotometric assay)

Synonym: AdoMet; SAM p-toluenesulfonate salt

CAS Number: 52248-03-0
Empirical Formula (Hill Notation): C₁₅H₂₃N₆O₅S · C₇H₇O₃S · xC₇H₈O₃S
Molecular Weight: 570.64 (free base basis)
Linear Formula: C₁₅H₂₃N₆O₅S · C₇H₇O₃S · xC₇H₈O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A2408-25MG	25 mg	$93.10 1/EA	Add To Favorites
45-A2408-100MG	100 mg	$190.00 1/EA	Add To Favorites
45-A2408-500MG	500 mg	$691.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2408-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥80% (HPLC)
	≥80% (spectrophotometric assay)
biological source	synthetic (Organic)
color	white to off-white
composition	p-Toluenesulfonate content, 1.6-4.4 mol/mol
form	powder
InChI	1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10)/t7-,8+,10+,11+,14+,27?;/m0./s1
InChI key	VHPOFDUCFKOUHV-XKGORWRGSA-N
Quality Level	300
shipped in	dry ice
SMILES string	O=C(O[H])[C@](N([H])[H])([H])C([H])([H])C([H])([H])[S@+](C([H])([H])[H])C([H])([H])[C@@]([C@](O[H])([H])[C@@]1([H])O[H])([H])O[C@]1([H])N2C3=C(N=C2[H])C(N([H])[H])=NC([H])=N3.O=S(C4=C([H])C([H])=C(C([H])([H])[H])C([H])=C4[H])([O-])=O
solubility	H₂O: 100 mg/mL
storage temp.	−20°C

Application:	S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.
Biochem/physiol Actions:	S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
Biochem/physiol Actions:	Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Caution:	This material is unstable at room temperature.
General description:	S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease.
Packaging:	25, 100, 500 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥80% (HPLC); ≥80% (spectrophotometric assay)
Storage Temp.	−20°C
UNSPSC	12352209

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