Cotrimoxazole, Ready Made Solution

SIGMA/A2487 - 100 mg/mL in DMSO

Synonym: Trimethoprim-Sulfamethoxazole; TMP-SMX

CAS Number: 8064-90-2
Empirical Formula (Hill Notation): C₁₄H₁₈N₄O₃· 5 C₁₀H₁₁N₃O₃S
Molecular Weight: 1556.71
Linear Formula: C₁₄H₁₈N₄O₃· 5 C₁₀H₁₁N₃O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A2487-1ML	1 mL	$619.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-negative bacteria
	Gram-positive bacteria
	parasites
color	colorless to faint yellow
concentration	100 mg/mL in DMSO
form	liquid
InChI	1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
InChI key	WZRJTRPJURQBRM-UHFFFAOYSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
shipped in	dry ice
storage temp.	−20°C

Application:	Cotrimoxazole has been used as an antimicrobial agent.
Biochem/physiol Actions:	Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	1ml
Preparation Note:	prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H317 - H361fd
Precautionary statements	P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
Hazard Codes	Xi
Risk Statements	36/37/38-43
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	51101500

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