N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide
SIGMA/A2559 - ≥97% (HPLC), powder
Synonym: Ac-DEVD-pNA
CAS Number: 189950-66-1
Empirical Formula (Hill Notation): C26H34N6O13
Molecular Weight: 638.58
MDL Number: MFCD00792707
Linear Formula: C26H34N6O13
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white |
form | powder |
InChI | 1S/C26H34N6O13/c1-12(2)22 |
InChI key | GGXRLUDNGFFUKI-ORGXJRBJSA |
Quality Level | 100 |
SMILES string | CC(C)[C@H](NC(=O)[C@H](CC |
storage temp. | −20°C |
Amino Acid Sequence: | NAc-Asp-Glu-Val-Asp-pNA |
Application: | N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines. |
Biochem/physiol Actions: | Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. |
Packaging: | 5 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352209 |