Asiatic acid

SIGMA/A2612 - ≥98% (HPLC), from Centella asiatica

Synonym: 2α,23-Dihydroxyursolic acid; Dammarolic acid; NSC 166063

CAS Number: 464-92-6
Empirical Formula (Hill Notation): C₃₀H₄₈O₅
Molecular Weight: 488.70
EC Number: 482-720-9
MDL Number: MFCD00238541
Linear Formula: C₃₀H₄₈O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A2612-10MG	10 mg	$367.00 1/EA	Add To Favorites
45-A2612-50MG	50 mg	$1180.00 1/EA	Add To Favorites

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This image depicts SKU: A2612-50MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
assay	≥98% (HPLC)
biological source	Centella asiatica
color	white
form	powder
InChI	1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
InChI key	JXSVIVRDWWRQRT-UYDOISQJSA-N
mp	325-330 °C (lit.)
Quality Level	200
SMILES string	C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
solubility	methanol: 1 mg/mL, clear, colorless
storage condition	protect from light
storage temp.	2-8°C

Application:	Asiatic acid has been used in the in vitro study of its cytotoxic potential in glioblastoma cells. It has also been used for the in vivo quantitative analysis of asiatic acid in Centella asiatica L. and in vitro study of enhancement of asiatic acid yield upon using organic elicitors.
Application:	Starting material for asiatic acid derivative synthesis for use as: • Anticancer agents • Glycogen phosphorylase inhibitors • Hepatoprotectants
Biochem/physiol Actions:	Asiatic acid has been reported to exhibit a pernicious effect on glioblastoma, breast, liver, melanoma, and colon cancers and anti-angiogenic activity. Additionally, it can cross the blood-brain barrier and cause apoptosis in human malignant glioma and hepatoma cells. Asiatic acid also effectively inhibits the Ultraviolet A modulated signal transduction pathways and thereby can be used against UVA-induced photoaging of the skin. It has been noted to show antinociceptive and anti-inflammatory properties plus inhibitory effect on neurotoxicity induced by β-amyloid and glutamate.
Biochem/physiol Actions:	Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties.
General description:	Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.
Packaging:	10 mg in glass bottle
Packaging:	50 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	325-330 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352212

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