Synonym: β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate; AMP-PNP; ATP[β,γ-NH]; Adenylyl imidodiphosphate lithium salt hydrate; App(NH)p
CAS Number: 25612-73-1 (free acid)
Empirical Formula (Hill Notation): C10H17N6O12P3 · xLi+ · yH2O
Molecular Weight: 506.20 (free acid basis)
Linear Formula: C10H17N6O12P3 · xLi+ · yH2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2647-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2647-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A2647-5MG
assay |
≥93% (HPLC) |
biological source |
natural (organic) |
color |
white |
form |
powder |
InChI |
1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1 |
InChI key |
PVKSNHVPLWYQGJ-KQYNXXCUSA-N |
Quality Level |
200 |
shipped in |
dry ice |
SMILES string |
[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O |
solubility |
H2O: 50 mg/mL |
storage temp. |
−20°C |
Application: |
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide. |
Biochem/physiol Actions: |
A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels. |
Caution: |
AMP-PNP is very unstable in acidic conditions; rapidly hydrolyzes to the phosphoramidate and inorganic phosphate. |
Packaging: |
100 mg in poly bottle |
Packaging: |
5, 25 mg in glass bottle |
Reconstitution: |
A 10 mg/mL stock solution may be made, aliquoted and stored at -70 °C for up to 3 months. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥93% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
41106305 |