[Val⁵]-Angiotensin II acetate salt hydrate

SIGMA/A2900 - ≥95% (HPLC), powder

Empirical Formula (Hill Notation): C₄₉H₆₉N₁₃O₁₂ · xC₂H₄O₂ · yH₂O
Molecular Weight: 1032.15 (anhydrous free base basis)
Linear Formula: C₄₉H₆₉N₁₃O₁₂ · xC₂H₄O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A2900-5MG	5 mg	$131.00 1/EA		Add To Favorites
45-A2900-50MG	50 mg	$777.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
composition	acetate, 1.2-10.4%
form	powder
InChI	1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1
InChI key	INQPQDZJLFYCRH-AXOAQIBVSA-N
Quality Level	200
SMILES string	O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
storage temp.	−20°C

Amino Acid Sequence:	Asp-Arg-Val-Tyr-Val-His-Pro-Phe
Application:	[Val5]-Angiotensin II acetate salt hydrate has been used to induce: • renal damage in mice to study the role of human liver-type fatty acid-binding protein (hL-FABP) • vascular inflammation in mice to study the interaction of cytosolic copper chaperone antioxidant-1 (Atox1) with tumor necrosis factor (TNF)-receptor-associated factor 4 (TRAF4) • abdominal aortic aneurysm (AAA) in mice to study the role of vascular ATPase copper transporting α (ATP7α)
Biochem/physiol Actions:	[Val5]-Angiotensin II acts as an agonist for the angiotensin II type 1 receptor (AT1 receptor).
General description:	[Val5]-Angiotensin II ([Val5]-ANG II) is an ANG II analog containing valine as the fifth amino acid in place of isoleucine in an ANG II octapeptide.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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