Amphotericin B solution

SIGMA/A2942 - 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

Synonym: Amphotericin; Fungizone

CAS Number: 1397-89-3
Empirical Formula (Hill Notation): C₄₇H₇₃NO₁₇
Molecular Weight: 924.08
MDL Number: MFCD00877763
Linear Formula: C₄₇H₇₃NO₁₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A2942-20ML	20 mL	$32.60 1/EA		Add To Favorites
45-A2942-50ML	50 mL	$77.30 1/EA		Add To Favorites
45-A2942-100ML	100 mL	$128.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	yeast
color	yellow
concentration	250 μg/mL in deionized water
form	liquid
InChI	1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key	APKFDSVGJQXUKY-INPOYWNPSA-N
mode of action	cell membrane \| interferes
product line	BioReagent
Quality Level	200
shipped in	dry ice
SMILES string	[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)O[Na])O2
sterility	0.1 μm filtered
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable

Application:	Amphotericin B solution has been used: • as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice • as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries • as a constituent of transport medium during the collection of equine corpora lutea • as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line
Biochem/physiol Actions:	Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. that is clinically used to treat systemic fungal infections. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.
Biochem/physiol Actions:	Amphotericin B is most effective against fungi and yeast. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules. Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses.
Disclaimer:	Amphotericin B remains active for 3 days in culture at 37°C.
General description:	Amphotericin B is a macrocyclic lactone with a hydrophilic polyhydroxyl chain and a lipophilic polyene based hydrocarbon chain.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
Other Notes:	This product is supplied as 250 μg/mL Amphotericin B in deionized water. It is a solution containing Amphotericin B, and the following components aimed to improve its solubility: sodium deoxycholate, sodium chloride and sodium phosphate.
Packaging:	20,50,100ml
Preparation Note:	It is not unusual for this material to form a precipitate in aqueous solutions. Mixing the solution will redissolve most of the precipitate but, if it does not fully resolubilize, the Amphotericin B will still be suitable for use.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352207

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