A-331440 L-tartrate hydrate

SIGMA/A3104 - ≥98% (HPLC), solid

Synonym: 4′-[3-[3(R)-Dimethylamino-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4′-carbonitrile L-tartrate hydrate

CAS Number: 392338-13-5 (free base)
Empirical Formula (Hill Notation): C₂₂H₂₇N₃O · xC₄H₆O₆ · yH₂O
Molecular Weight: 349.47 (anhydrous free base basis)
Linear Formula: C₂₂H₂₇N₃O · xC₄H₆O₆ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A3104-25MG	25 mg	$476.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	solid
InChI	1S/C22H27N3O.C4H6O6.H2O/c1-24(2)21-12-14-25(17-21)13-3-15-26-22-10-8-20(9-11-22)19-6-4-18(16-23)5-7-19;5-1(3(7)8)2(6)4(9)10;/h4-11,21H,3,12-15,17H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10);1H2/t21-;1-,2-;/m11./s1
InChI key	BWZMVOINNVPOGW-LZXZYUBDSA-N
originator	Abbott
Quality Level	100
SMILES string	[H]O[H].O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(C)[C@@H]1CCN(CCCOc2ccc(cc2)-c3ccc(cc3)C#N)C1
solubility	DMSO: ≥10 mg/mL
	ethanol: insoluble
	H₂O: insoluble
	methanol: insoluble

Biochem/physiol Actions:	A-331430 L-tartrate hydrate is a non-imidazole H₃histamine receptor antagonist.
Biochem/physiol Actions:	Histamine affects homeostatic mechanisms, including food and water consumption, by acting on central nervous system (CNS) receptors. Presynaptic histamine H₃ receptors regulate release of histamine and other neurotransmitters, and histamine H₃receptor antagonists enhance neurotransmitter release. A-331440 [4′-[3-(3(R)-(dimethylami<WBR>no)-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile] is a histamine H₃ receptor antagonist which binds potently and selectively to both human and rat histamine H₃ receptors (K_i<=25 nM). Mice were stabilized on a high-fat diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-fat diet. The two higher doses reduced body fat and the highest dose also normalized an insulin tolerance test. These data show that the histamine H₃receptor antagonist, A-331440, has potential as an antiobesity agent.
Features and Benefits:	This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Legal Information:	Subject to U.S. Patent numbers 6,515,013 and 6,620,839. Sold under license from Abbott Laboratories
Packaging:	25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
UNSPSC	12352202

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