A-803467
SIGMA/A3109 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 944261-79-4
Empirical Formula (Hill Notation): C19H16NO4Cl
Molecular Weight: 357.79
MDL Number: MFCD10574689
Linear Formula: C19H16NO4Cl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C19H16ClNO4/c1-23-15-9 |
| InChI key | VHKBTPQDHDSBSP-UHFFFAOYSA |
| originator | Abbott |
| Quality Level | 100  |
| SMILES string | COc1cc(NC(=O)c2ccc(o2)-c3 |
| solubility | DMSO: >10 mg/mL |
| storage temp. | room temp |
| Biochem/physiol Actions: | A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. |
| Features and Benefits: | This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects. A-803467 decreases the firing in spinal dorsal horn neurons in vivo. |
| General description: | The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic. |
| Packaging: | 10, 50 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |