3-Aminopropionitrile fumarate salt
SIGMA/A3134 - metabolite
Synonym: β-Alaninenitrile
CAS Number: 2079-89-2
Empirical Formula (Hill Notation): C3H6N2 · 0.5C4H4O4
Molecular Weight: 128.13
EC Number: 218-208-7
Linear Formula: NH2CH2CH2CN · ½ (HO2CCH=CHCO2H)
Product Type: Chemical
assay | ≥98% (TLC) |
biological source | synthetic (organic) |
form | powder |
InChI | 1S/C4H4O4.2C3H6N2/c5-3(6) |
InChI key | NYMXYZMHOZAPHQ-SEPHDYHBSA |
mp | 177 °C (dec.) (lit.) |
Quality Level | 200 |
SMILES string | NCCC#N.NCCC#N.OC(=O)C=C |
solubility | water: 50 mg/mL, clear, colorless to faintly yellow |
Application: | 3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor: • to inhibit collagen cross-linking during microtissue formation and culture • in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay • in lysyl oxidase (LOX) activity assay • to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids |
Biochem/physiol Actions: | 3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking. |
Biochem/physiol Actions: | In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway. |
Packaging: | 5, 10, 25 g in poly bottle |
Symbol | GHS08 |
Signal word | Danger |
Hazard statements | H360FD |
Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
Hazard Codes | T |
Risk Statements | 61 |
Safety Statements | 53-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (TLC) |
mp | 177 °C (dec.) (lit.) |
UNSPSC | 12352202 |