Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ trifluoroacetate salt

SIGMA/A3227 - ≥98% (HPLC), lyophilized powder

Synonym: AYPGKF-NH₂; PAR4-AP

Empirical Formula (Hill Notation): C₃₄H₄₈N₈O₇ · xC₂HF₃O₂
Molecular Weight: 680.79 (free base basis)
MDL Number: MFCD04974484
Linear Formula: C₃₄H₄₈N₈O₇ · xC₂HF₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A3227-1MG	1 mg	$205.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	lyophilized powder
InChI	1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
InChI key	BGPJLFVICWHITH-HKJXYENISA-N
Quality Level	100
SMILES string	OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
solubility	H₂O: >10 mg/mL
storage temp.	−20°C

Amino Acid Sequence:	Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Application:	4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.
Application:	AYPGKF- NH₂ may be used for probing PAR4 signaling in culture systems and in platelets.
Biochem/physiol Actions:	AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.
General description:	Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ (AYPGKF- NH₂) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.
Packaging:	1 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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