AR-A014418

SIGMA/A3230 - ≥98% (HPLC), solid

Synonym: N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea

CAS Number: 487021-52-3
Empirical Formula (Hill Notation): C₁₂H₁₂N₄O₄S
Molecular Weight: 308.31
MDL Number: MFCD08277040
Linear Formula: C₁₂H₁₂N₄O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A3230-5MG	5 mg	$206.00 1/EA		Add To Favorites
45-A3230-25MG	25 mg	$702.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white to tan
form	solid
InChI	1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
InChI key	YAEMHJKFIIIULI-UHFFFAOYSA-N
originator	AstraZeneca
Quality Level	100
SMILES string	COc1ccc(CNC(=O)Nc2ncc(s2)[N+]([O-])=O)cc1
solubility	DMSO: ≥20 mg/mL, clear, light yellow
	H₂O: insoluble
storage temp.	2-8°C

Application:	AR-A014418 has been used as an inhibitor of glycogen synthase kinase 3 (GSK3).
Biochem/physiol Actions:	Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC₅₀ = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC₅₀> 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.
Features and Benefits:	This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	AR-A014418 may have chronic pain-relieving properties. In mice having neuropathic pain, this molecule has been shown to have antihyperalgesic effects. AR-A014418 may modulate proinflammatory cytokines and the catecholaminergic and serotonergic pathways. It has also been studied that AR-A014418 inhibits growth of pancreatic cancer cells.
Packaging:	5 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22-37/38-41
Safety Statements	26-36/39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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