Atosiban

SIGMA/A3480 - ≥98% (HPLC)

Synonym: 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin; 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin; Tractocile

CAS Number: 90779-69-4
Empirical Formula (Hill Notation): C₄₃H₆₇N₁₁O₁₂S₂
Molecular Weight: 994.19
MDL Number: MFCD00672436
Linear Formula: C₄₃H₆₇N₁₁O₁₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A3480-10MG	10 mg	$324.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	lyophilized powder
InChI	1S/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36-/m0/s1
InChI key	VWXRQYYUEIYXCZ-OBIMUBPZSA-N
originator	Ferring
Quality Level	100
shipped in	wet ice
SMILES string	[H][C@]1(NC(=O)[C@@]([H])(NC(=O)[C@@H](Cc2ccc(OCC)cc2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)[C@@H](C)CC)[C@@H](C)O
solubility	H₂O: ≤100 mg/mL
storage condition	desiccated
storage temp.	−20°C

Application:	Atosiban has been used: • as an oxytocin receptor antagonist • in the calcium mobilization assay for Z factor determination in uterine myometrium (UT-myo cells) and as a therapeutic agent to inhibit preterm labor • to inhibit the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (Oxtr^PBN)
Biochem/physiol Actions:	Atosiban efficiently prevent preterm uterine contractions without any major cardiovascular, pulmonary or central nervous system side effects. It has potential to treat preterm labour.
Biochem/physiol Actions:	Atosiban is a peptide oxytocin receptor antagonist.
Features and Benefits:	This compound was developed by Ferring . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10 mg in glass bottle
Preparation Note:	Reconstitute in deionized water at not less than 100 μg/mL, which can then be diluted into aqueous vehicle of choice. Solutions may be stored at 2-8 °C for up to seven days. For extended storage, add a carrier protein of 0.1% human serum albumin or bovine serum albumin and freeze in working aliquots at −20 °C.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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