2-Aminopurine
SIGMA/A3509 - ≥99%
Synonym: 2-AP
CAS Number: 452-06-2
Empirical Formula (Hill Notation): C5H5N5
Molecular Weight: 135.13
EC Number: 207-197-4
MDL Number: MFCD00005566
Linear Formula: C5H5N5
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A3509-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A3509-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A3509-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A3509-500MG
| assay | ≥99% |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C5H5N5/c6-5-7-1-3-4(10 |
| InChI key | MWBWWFOAEOYUST-UHFFFAOYSA |
| mp | 280-282 °C (lit.) |
| Quality Level | 200  |
| SMILES string | Nc1ncc2[nH]cnc2n1 |
| storage temp. | 2-8°C |
| Application: | 2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR). |
| Application: | 2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes. |
| Biochem/physiol Actions: | 2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR). |
| Packaging: | 1 g in poly bottle |
| Packaging: | 100, 250, 500 mg in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| mp | 280-282 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41106305 |