Artesunate

SIGMA/A3731 - from Artemisia annua

Synonym: Artesunic acid; dihydroartemisinine-12-alpha-succinate; succinyl dihydroartemisinin

CAS Number: 88495-63-0
Empirical Formula (Hill Notation): C₁₉H₂₈O₈
Molecular Weight: 384.42
MDL Number: MFCD00866204
Linear Formula: C₁₉H₂₈O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A3731-100MG	100 mg	$457.00 1/EA	Add To Favorites
45-A3731-500MG	500 mg	$881.00 1/EA	Add To Favorites

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This image depicts SKU: A3731-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
	parasites
biological source	Artemisia annua
color	white to off-white
form	crystalline powder
InChI	1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1
InChI key	FIHJKUPKCHIPAT-JQXDXKTESA-N
mode of action	protein synthesis \| interferes
Quality Level	100
SMILES string	O1OC2(O[C@H]3O[C@@H]([C@@H]([C@H]4[C@]31[C@H]([C@@H](CC4)C)CC2)C)OC(=O)CCC(=O)O)C
solubility	acetone: 33.4 mg/mL
storage temp.	room temp

Application:	Unrevealing the therapeutic potential of artesunate against emerging zoonotic Babesia microti infection in the murine model.: This study explores the efficacy of artesunate in treating Babesia microti infection, a zoonotic disease, in mice. The findings suggest that artesunate significantly reduces parasitemia, indicating its potential as a therapeutic agent for zoonotic infections (Fazilani et al., 2024 ). Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells.: The study investigates artesunate′s antitumor properties in oesophageal squamous carcinoma cells, highlighting its ability to regulate cell cycle checkpoints and inhibit cancer cell proliferation. These findings underscore artesunate′s potential in cancer therapy (Mao et al., 2024 ). 3D printing of multi-unit gastro-retentive tablets for the pulsatile release of artesunate.: This study presents a novel approach to drug delivery using 3D-printed gastro-retentive tablets for the pulsatile release of artesunate. The technology promises improved bioavailability and therapeutic efficacy of artesunate for various medical conditions (Yan et al., 2024 ).
Biochem/physiol Actions:	Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.
General description:	Artesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging:	100, 500 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 + H312 + H332
Precautionary statements	P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Codes	Xn
Risk Statements	20/21/22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	room temp
UNSPSC	51101914

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